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- Title
The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.
- Authors
Koch, M; Rett, K; Volk, A; Maerker, E; Haist, K; Weisser, M; Rettig, A; Renn, W; Häring, H U
- Abstract
Tumour necrosis factor-alpha (TNF-alpha) is believed to influence skeletal muscle insulin resistance. Two G --> A transitions in the promoter region of TNF-alpha at position -238 and -308 have been identified that could play a part in transcriptional regulation of the gene. Insulin resistance is an independent familial trait that predicts the development of Type II (non-insulin-dependent) diabetes mellitus. We investigated the influence on insulin sensitivity and insulin secretion of both polymorphisms in a cohort of young healthy relatives of patients with Type II diabetes.
- Publication
Diabetologia, 2000, Vol 43, Issue 2, p181
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s001250050027