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- Title
Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.
- Authors
Yamada, S; Zhu, Q; Aihara, Y; Onda, H; Zhang, Z; Yu, L; Jin, L; Si, Y J; Nishigori, H; Tomura, H; Inoue, I; Morikawa, A; Yamagata, K; Hanafusa, T; Matsuzawa, Y; Takeda, J
- Abstract
Molecular defects of the genes for transcription factors, hepatocyte nuclear factor (HNF)-4 alpha, HNF-1 alpha, HNF-1 beta and insulin promoter factor-1 cause maturity-onset diabetes of the young (MODY1, 3, 5, and 4, respectively). This suggests the HNF-related transcription cascade is important in insulin secretion which is induced by glucose. These genes and the gene encoding glycolytic enzyme glucokinase (MODY2) are, however, responsible for only 15-20% of cases of MODY in the Japanese. Searching for a novel form of MODY in this population, we cloned a new candidate gene encoding human HNF-3 beta, a winged helix transcription factor, which also belongs to the same HNF-transcription cascade.
- Publication
Diabetologia, 2000, Vol 43, Issue 1, p121
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s001250050016