We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Differences in metabolic and mitogenic signallingof insulin glargine and AspB10 human insulin in rats [corrected].
- Authors
Tennagels, N; Welte, S; Hofmann, M; Brenk, P; Schmidt, R; Werner, U
- Abstract
In vitro, insulin glargine (A21Gly,B31Arg,B32Arg human insulin) has an insulin receptor (IR) profile similar to that of human insulin, but a slightly higher affinity for the IGF-1 receptor (IGF1R). AspB10 human insulin (AspB10), [corrected] the only insulin analogue with proven carcinogenic activity, has a greater affinity for IGF1R and IR, and a prolonged IR occupancy time. The pharmacological and signalling profile of therapeutic and suprapharmacological doses of glargine were analysed in different tissues of rats, and compared with human insulin and AspB10.
- Publication
Diabetologia, 2013, Vol 56, Issue 8, p1826
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-013-2923-z