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- Title
AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle.
- Authors
Lee-Young, R S; Bonner, J S; Mayes, W H; Iwueke, I; Barrick, B A; Hasenour, C M; Kang, L; Wasserman, D H
- Abstract
We determined whether: (1) an acute lipid infusion impairs skeletal muscle AMP-activated protein kinase (AMPK)α2 activity, increases inducible nitric oxide synthase (iNOS) and causes peripheral insulin resistance in conscious, unstressed, lean mice; and (2) restoration of AMPKα2 activity during the lipid infusion attenuates the increase in iNOS and reverses the defect in insulin sensitivity in vivo.
- Publication
Diabetologia, 2013, Vol 56, Issue 3, p608
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-012-2787-7