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- Title
In vitro scan for enhancers at the TCF7L2 locus.
- Authors
Savic, D; Park, S Y; Bailey, K A; Bell, G I; Nobrega, M A
- Abstract
Recent functional characterisations of genome-wide association study (GWAS) loci suggest that cis-regulatory variation may be a common paradigm for complex disease susceptibility. Several studies point to a similar mechanism at the transcription factor 7-like 2 (TCF7L2) GWAS locus for type 2 diabetes. To address this possibility, we carried out an in vitro scan of this diabetes-associated locus to fine-map cis-regulatory sequences within this genomic interval.
- Publication
Diabetologia, 2013, Vol 56, Issue 1, p121
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-012-2730-y