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- Title
Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men.
- Authors
Jacobsen, S C; Brøns, C; Bork-Jensen, J; Ribel-Madsen, R; Yang, B; Lara, E; Hall, E; Calvanese, V; Nilsson, E; Jørgensen, S W; Mandrup, S; Ling, C; Fernandez, A F; Fraga, M F; Poulsen, P; Vaag, A
- Abstract
Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.
- Publication
Diabetologia, 2012, Vol 55, Issue 12, p3341
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-012-2717-8