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- Title
The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study.
- Authors
Scott, R A; Langenberg, C; Sharp, S J; Franks, P W; Rolandsson, O; Drogan, D; van der Schouw, Y T; Ekelund, U; Kerrison, N D; Ardanaz, E; Arriola, L; Balkau, B; Barricarte, A; Barroso, I; Bendinelli, B; Beulens, J W J; Boeing, H; de Lauzon-Guillain, B; Deloukas, P; Fagherazzi, G; Gonzalez, C; Griffin, S J; Groop, L C; Halkjaer, J; Huerta, J M; Kaaks, R; Khaw, K T; Krogh, V; Nilsson, P M; Norat, T; Overvad, K; Panico, S; Rodriguez-Suarez, L; Romaguera, D; Romieu, I; Sacerdote, C; Sánchez, M J; Spijkerman, A M W; Teucher, B; Tjonneland, A; Tumino, R; van der A, D L; Wark, P A; McCarthy, M I; Riboli, E; Wareham, N J; InterAct Consortium
- Abstract
Although a family history of type 2 diabetes is a strong risk factor for the disease, the factors mediating this excess risk are poorly understood. In the InterAct case-cohort study, we investigated the association between a family history of diabetes among different family members and the incidence of type 2 diabetes, as well as the extent to which genetic, anthropometric and lifestyle risk factors mediated this association.
- Publication
Diabetologia, 2013, Vol 56, Issue 1, p60
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-012-2715-x