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- Title
Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction.
- Authors
Ylipaasto, P; Smura, T; Gopalacharyulu, P; Paananen, A; Seppänen-Laakso, T; Kaijalainen, S; Ahlfors, H; Korsgren, O; Lakey, J R T; Lahesmaa, R; Piemonti, L; Oresic, M; Galama, J; Roivainen, M
- Abstract
Virally induced inflammatory responses, beta cell destruction and release of beta cell autoantigens may lead to autoimmune reactions culminating in type 1 diabetes. Therefore, viral capability to induce beta cell death and the nature of virus-induced immune responses are among key determinants of diabetogenic viruses. We hypothesised that enterovirus infection induces a specific gene expression pattern that results in islet destruction and that such a host response pattern is not shared among all enterovirus infections but varies between virus strains.
- Publication
Diabetologia, 2012, Vol 55, Issue 12, p3273
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-012-2713-z