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- Title
Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.
- Authors
Parker, H E; Adriaenssens, A; Rogers, G; Richards, P; Koepsell, H; Reimann, F; Gribble, F M
- Abstract
Several glucose-sensing pathways have been implicated in glucose-triggered secretion of glucagon-like peptide-1 (GLP-1) from intestinal L cells. One involves glucose metabolism and closure of ATP-sensitive K(+) channels, and another exploits the electrogenic nature of Na(+)-coupled glucose transporters (SGLTs). This study aimed to elucidate the role of these distinct mechanisms in glucose-stimulated GLP-1 secretion.
- Publication
Diabetologia, 2012, Vol 55, Issue 9, p2445
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-012-2585-2