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Title
Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity.
Authors
Zhou, B; Li, C; Qi, W; Zhang, Y; Zhang, F; Wu, J X; Hu, Y N; Wu, D M; Liu, Y; Yan, T T; Jing, Q; Liu, M F; Zhai, Q W
Abstract
Sirtuin-1 (SIRT1) is a potential therapeutic target to combat insulin resistance and type 2 diabetes. This study aims to identify a microRNA (miRNA) targeting SIRT1 to regulate hepatic insulin sensitivity.