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- Title
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance.
- Authors
Maris, M; Overbergh, L; Gysemans, C; Waget, A; Cardozo, A K; Verdrengh, E; Cunha, J P M; Gotoh, T; Cnop, M; Eizirik, D L; Burcelin, R; Mathieu, C
- Abstract
Endoplasmic reticulum (ER) stress has been implicated in the development of type 2 diabetes, via effects on obesity, insulin resistance and pancreatic beta cell health. C/EBP homologous protein (CHOP) is induced by ER stress and has a central role in apoptotic execution pathways triggered by ER stress. The aim of this study was to characterise the role of CHOP in obesity and insulin resistance.
- Publication
Diabetologia, 2012, Vol 55, Issue 4, p1167
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-011-2427-7