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- Title
Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.
- Authors
Norton, L; Fourcaudot, M; Abdul-Ghani, M A; Winnier, D; Mehta, F F; Jenkinson, C P; Defronzo, R A
- Abstract
The mechanisms by which transcription factor 7-like 2 (TCF7L2) regulates the pathways that are important in the pathogenesis of type 2 diabetes are unknown. We therefore examined the role of TCF7L2 in hepatic glucose production (HGP) in vitro and characterised the whole-genome chromatin occupancy of TCF7L2 in hepatocytes.
- Publication
Diabetologia, 2011, Vol 54, Issue 12, p3132
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-011-2289-z