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- Title
Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.
- Authors
Pinney, S E; Jaeckle Santos, L J; Han, Y; Stoffers, D A; Simmons, R A
- Abstract
The abnormal intrauterine milieu of intrauterine growth retardation (IUGR) permanently alters gene expression and function of pancreatic beta cells leading to the development of diabetes in adulthood. Expression of the pancreatic homeobox transcription factor Pdx1 is permanently reduced in IUGR islets suggesting an epigenetic mechanism. Exendin-4 (Ex-4), a long-acting glucagon-like peptide-1 (GLP-1) analogue, given in the newborn period increases Pdx1 expression and prevents the development of diabetes in the IUGR rat.
- Publication
Diabetologia, 2011, Vol 54, Issue 10, p2606
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-011-2250-1