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- Title
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.
- Authors
Hogan, A E; Tobin, A M; Ahern, T; Corrigan, M A; Gaoatswe, G; Jackson, R; O'Reilly, V; Lynch, L; Doherty, D G; Moynagh, P N; Kirby, B; O'Connell, J; O'Shea, D
- Abstract
The innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, such as diabetes and dyslipidaemia. We observed an improvement in psoriasis severity in a patient within days of starting treatment with an incretin-mimetic, glucagon-like peptide-1 (GLP-1) receptor agonist. This was independent of change in glycaemic control. We proposed that this unexpected clinical outcome resulted from a direct effect of GLP-1 on iNKT cells.
- Publication
Diabetologia, 2011, Vol 54, Issue 11, p2745
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-011-2232-3