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- Title
Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus--an adaptive response to hyperglycaemia?
- Authors
Hansen, A M K; Bödvarsdottir, T B; Nordestgaard, D N E; Heller, R S; Gotfredsen, C F; Maedler, K; Fels, J J; Holst, J J; Karlsen, A E
- Abstract
The hormone glucagon-like peptide 1 (GLP-1) is released in response to a meal from the intestinal L-cells, where it is processed from proglucagon by the proconvertase (PC)1/3. In contrast, in the adult islets proglucagon is processed to glucagon by the PC2 enzyme. The aim of the study was to evaluate if, during the development of diabetes, alpha cells produce GLP-1 that, in turn, might trigger beta cell growth.
- Publication
Diabetologia, 2011, Vol 54, Issue 6, p1379
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-011-2080-1