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Title
Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.
Authors
Jermendy, A; Toschi, E; Aye, T; Koh, A; Aguayo-Mazzucato, C; Sharma, A; Weir, G C; Sgroi, D; Bonner-Weir, S
Abstract
Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. We hypothesise that this unresponsiveness is due to a generalised immaturity of the metabolic pathways normally found in beta cells rather than to a specific defect.