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- Title
Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients.
- Authors
Pugazhenthi, U; Velmurugan, K; Tran, A; Mahaffey, G; Pugazhenthi, S
- Abstract
Exendin-4, a glucagon-like peptide-1 (GLP-1) analogue, is reported to have modest anti-inflammatory effects in addition to that of improving beta cell survival. We therefore sought to determine whether exendin-4 decreases expression of the gene encoding chemokine (C-X-C motif) ligand (CXCL)10, which plays a role in initiating insulitis in type 1 diabetes.
- Publication
Diabetologia, 2010, Vol 53, Issue 11, p2357
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-010-1849-y