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- Title
Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein.
- Authors
Mughal, R S; Scragg, J L; Lister, P; Warburton, P; Riches, K; O'Regan, D J; Ball, S G; Turner, N A; Porter, K E
- Abstract
Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in the development of intimal hyperplasia in saphenous vein (SV) bypass grafts. In diabetic patients, insulin administration controls hyperglycaemia but cardiovascular complications remain. Insulin is synthesised as a pro-peptide, from which C-peptide is cleaved and released into the circulation with insulin; exogenous insulin lacks C-peptide. Here we investigate modulation of human SV neointima formation and SV-EC and SV-SMC function by insulin and C-peptide.
- Publication
Diabetologia, 2010, Vol 53, Issue 8, p1761
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-010-1736-6