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- Title
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.
- Authors
Igoillo-Esteve, M; Marselli, L; Cunha, D A; Ladrière, L; Ortis, F; Grieco, F A; Dotta, F; Weir, G C; Marchetti, P; Eizirik, D L; Cnop, M
- Abstract
Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. One of the proposed mechanisms of beta cell failure is local inflammation, but the presence of pancreatic islet inflammation in type 2 diabetes and the mechanisms involved remain under debate.
- Publication
Diabetologia, 2010, Vol 53, Issue 7, p1395
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-010-1707-y