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- Title
In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy.
- Authors
Villiger, M; Goulley, J; Friedrich, M; Grapin-Botton, A; Meda, P; Lasser, T; Leitgeb, R A
- Abstract
Structural and functional imaging of the islets of Langerhans and the insulin-secreting beta cells represents a significant challenge and a long-lasting objective in diabetes research. In vivo microscopy offers a valuable insight into beta cell function but has severe limitations regarding sample labelling, imaging speed and depth, and was primarily performed on isolated islets lacking native innervations and vascularisation. This article introduces extended-focus optical coherence microscopy (xfOCM) to image murine pancreatic islets in their natural environment in situ, i.e. in vivo and in a label-free condition.
- Publication
Diabetologia, 2009, Vol 52, Issue 8, p1599
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-009-1383-y