We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line.
- Authors
Sarkar, S A; Kutlu, B; Velmurugan, K; Kizaka-Kondoh, S; Lee, C E; Wong, R; Valentine, A; Davidson, H W; Hutton, J C; Pugazhenthi, S
- Abstract
The destruction of pancreatic beta cells leading to type 1 diabetes in humans is thought to occur mainly through apoptosis and necrosis induced by activated macrophages and T cells, and in which secreted cytokines play a significant role. The transcription factor nuclear factor kappa-B (NF-kappaB) plays an important role in mediating the apoptotic action of cytokines in beta cells. We therefore sought to determine the changes in expression of genes modulated by NF-kappaB in human islets exposed to a combination of IL1beta, TNF-alpha and IFN-gamma.
- Publication
Diabetologia, 2009, Vol 52, Issue 6, p1092
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-009-1331-x