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- Title
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress.
- Authors
Hull, R L; Zraika, S; Udayasankar, J; Aston-Mourney, K; Subramanian, S L; Kahn, S E
- Abstract
Supraphysiological levels of the amyloidogenic peptide human islet amyloid polypeptide have been associated with beta cell endoplasmic reticulum (ER) stress. However, in human type 2 diabetes, levels of human IAPP are equivalent or decreased relative to matched controls. Thus, we sought to investigate whether ER stress is induced during amyloidogenesis at physiological levels of human IAPP.
- Publication
Diabetologia, 2009, Vol 52, Issue 6, p1102
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-009-1329-4