We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
- Authors
Osmark, P; Hansson, O; Jonsson, A; Rönn, T; Groop, L; Renström, E
- Abstract
Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.
- Publication
Diabetologia, 2009, Vol 52, Issue 5, p850
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-009-1293-z