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- Title
TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.
- Authors
Stolerman, E S; Manning, A K; McAteer, J B; Fox, C S; Dupuis, J; Meigs, J B; Florez, J C
- Abstract
Common variants in the TCF7L2 gene are associated with type 2 diabetes via impaired insulin secretion. One hypothesis is that variation in TCF7L2 impairs insulin processing in the beta cell. In contrast, the association of related TCF7L2 polymorphisms with obesity is controversial in that it has only been shown in cohorts susceptible to ascertainment bias. We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS).
- Publication
Diabetologia, 2009, Vol 52, Issue 4, p614
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-009-1266-2