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- Title
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.
- Authors
Coletta, D K; Sriwijitkamol, A; Wajcberg, E; Tantiwong, P; Li, M; Prentki, M; Madiraju, M; Jenkinson, C P; Cersosimo, E; Musi, N; Defronzo, R A
- Abstract
The molecular mechanisms by which thiazolidinediones improve insulin sensitivity in type 2 diabetes are not fully understood. We hypothesised that pioglitazone would activate the adenosine 5'-monophosphate-activated protein kinase (AMPK) pathway and increase the expression of genes involved in adiponectin signalling, NEFA oxidation and mitochondrial function in human skeletal muscle.
- Publication
Diabetologia, 2009, Vol 52, Issue 4, p723
- ISSN
1432-0428
- Publication type
Journal Article
- DOI
10.1007/s00125-008-1256-9