We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A genetic link between type 2 diabetes and prostate cancer.
- Authors
Frayling, T M; Colhoun, H; Florez, J C
- Abstract
Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.
- Publication
Diabetologia, 2008, Vol 51, Issue 10, p1757
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-008-1114-9