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- Title
Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection.
- Authors
Rønn, S G; Börjesson, A; Bruun, C; Heding, P E; Frobøse, H; Mandrup-Poulsen, T; Karlsen, A E; Rasschaert, J; Sandler, S; Billestrup, N
- Abstract
The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.
- Publication
Diabetologia, 2008, Vol 51, Issue 10, p1873
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-008-1090-0