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- Title
A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
- Authors
Pearson, T; Shultz, L D; Lief, J; Burzenski, L; Gott, B; Chase, T; Foreman, O; Rossini, A A; Bottino, R; Trucco, M; Greiner, D L
- Abstract
To develop and validate a new immunodeficient mouse strain that spontaneously develops a non-autoimmune hyperglycaemia to serve as a diabetic host for human islets and human beta stem and progenitor cells without the need for induction of hyperglycaemia by toxic chemicals with their associated side effects.
- Publication
Diabetologia, 2008, Vol 51, Issue 8, p1449
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-008-1057-1