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- Title
Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.
- Authors
Ellard, S; Bellanné-Chantelot, C; Hattersley, A T; European Molecular Genetics Quality Network (EMQN) MODY group
- Abstract
Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive insulin secretory defect is seen in patients with mutations in the HNF1A and HNF4A genes encoding the transcription factors hepatocyte nuclear factor-1 alpha and -4 alpha. A molecular genetic diagnosis often changes management, since patients with GCK mutations rarely require pharmacological treatment and HNF1A/4A mutation carriers are sensitive to sulfonylureas. These monogenic forms of diabetes are often misdiagnosed as type 1 or 2 diabetes. Best practice guidelines for genetic testing were developed to guide testing and reporting of results.
- Publication
Diabetologia, 2008, Vol 51, Issue 4, p546
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-008-0942-y