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Title
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.
Authors
Marchetti, P; Bugliani, M; Lupi, R; Marselli, L; Masini, M; Boggi, U; Filipponi, F; Weir, G C; Eizirik, D L; Cnop, M
Abstract
Pancreatic beta cells have highly developed endoplasmic reticulum (ER) due to their role in insulin secretion. Since ER stress has been associated with beta cell dysfunction, we studied several features of beta cell ER in human type 2 diabetes.