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- Title
IGF-1 receptor signalling determines the mitogenic potency of insulin analogues in human smooth muscle cells and fibroblasts.
- Authors
Eckardt, K; May, C; Koenen, M; Eckel, J
- Abstract
Mitogenic activity of insulin and insulin analogues and the involvement of the IGF-1 receptor (IGF-1R) is still a controversial issue. We compared levels of the proteins IGF-1R and insulin receptor (InsR) in fibroblasts and smooth muscle cells from healthy donors and assessed the downstream signalling and growth-promoting activity of insulin and insulin analogues.
- Publication
Diabetologia, 2007, Vol 50, Issue 12, p2534
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-007-0815-9