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- Title
Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.
- Authors
Sarkar, S A; Gunter, J; Bouchard, R; Reusch, J E-B; Wiseman, A; Gill, R G; Hutton, J C; Pugazhenthi, S
- Abstract
Transplantation of islets is a viable option for the treatment of diabetes. A significant proportion of islets is lost during isolation, storage and after transplantation as a result of apoptosis. cAMP response element binding protein (CREB) is an important cell survival factor. The aim of the present study was to determine whether preservation of CREB function is needed for survival of human islets.
- Publication
Diabetologia, 2007, Vol 50, Issue 8, p1649
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-007-0707-z