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- Title
Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina.
- Authors
Hughes, J M; Kuiper, E J; Klaassen, I; Canning, P; Stitt, A W; Van Bezu, J; Schalkwijk, C G; Van Noorden, C J F; Schlingemann, R O
- Abstract
Referred to as CCN, the family of growth factors consisting of cystein-rich protein 61 (CYR61, also known as CCN1), connective tissue growth factor (CTGF, also known as CCN2), nephroblastoma overexpressed gene (NOV, also known as CCN3) and WNT1-inducible signalling pathway proteins 1, 2 and 3 (WISP1, -2 and -3; also known as CCN4, -5 and -6) affects cellular growth, differentiation, adhesion and locomotion in wound repair, fibrotic disorders, inflammation and angiogenesis. AGEs formed in the diabetic milieu affect the same processes, leading to diabetic complications including diabetic retinopathy. We hypothesised that pathological effects of AGEs in the diabetic retina are a consequence of AGE-induced alterations in CCN family expression.
- Publication
Diabetologia, 2007, Vol 50, Issue 5, p1089
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-007-0621-4