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- Title
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
- Authors
Howson, J M M; Dunger, D B; Nutland, S; Stevens, H; Wicker, L S; Todd, J A
- Abstract
HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes and autoimmune thyroid disease. Using thyroid peroxidase autoantibodies (TPOAbs) as an indicator of thyroid autoimmunity, we assessed whether the association of these loci is different in type 1 diabetes patients with TPOAbs than in those without.
- Publication
Diabetologia, 2007, Vol 50, Issue 4, p741
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-007-0603-6