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- Title
Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy.
- Authors
Li, R; Thorens, B; Loeken, M R
- Abstract
Excess glucose transport to embryos during diabetic pregnancy causes congenital malformations. The early postimplantation embryo expresses the gene encoding the high-Km GLUT2 (also known as SLC2A2) glucose transporter. The hypothesis tested here is that high-Km glucose transport by GLUT2 causes malformations resulting from maternal hyperglycaemia during diabetic pregnancy.
- Publication
Diabetologia, 2007, Vol 50, Issue 3, p682
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0579-7