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- Title
Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity.
- Authors
García-Herrero, C M; Galán, M; Vincent, O; Flández, B; Gargallo, M; Delgado-Alvarez, E; Blázquez, E; Navas, M A
- Abstract
Glucokinase (GCK) acts as a glucose sensor in the pancreatic beta cell and regulates insulin secretion. In the gene encoding GCK the heterozygous mutations that result in enzyme inactivation cause MODY2. Functional studies of naturally occurring GCK mutations associated with hyperglycaemia provide further insight into the biochemical basis of glucose sensor regulation.
- Publication
Diabetologia, 2007, Vol 50, Issue 2, p325
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0542-7