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- Title
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
- Authors
Collins, S C; Luan, J; Thompson, A J; Daly, A; Semple, R K; O'Rahilly, S; Wareham, N J; Barroso, I
- Abstract
Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. Several reports suggest that genetic variants in the adiponectin gene are associated with circulating levels of adiponectin, insulin sensitivity and type 2 diabetes risk. Recently two receptors for adiponectin have been cloned. Genetic studies have yielded conflicting results on the role of these genes and type 2 diabetes predisposition. In this study we aimed to evaluate the potential role of genetic variation in these genes in syndromes of severe insulin resistance, type 2 diabetes and in related metabolic traits in UK Europid populations.
- Publication
Diabetologia, 2007, Vol 50, Issue 3, p555
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0534-7