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- Title
The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells.
- Authors
Bussiere, C T; Lakey, J R T; Shapiro, A M J; Korbutt, G S
- Abstract
The Edmonton Protocol for islet transplantation has provided hope for type 1 diabetic patients. However, this protocol requires lifelong immunosuppression, specifically sirolimus, a cellular antiproliferate. The effect of sirolimus on human pancreatic ductal cells (HDCs) is not known. This may be important since HDCs are believed to be islet precursors. Since neonatal porcine islets (NPIs), which contain many ductal precursor cells, could be a potential clinical source of islets, we also tested the effects of sirolimus on this tissue.
- Publication
Diabetologia, 2006, Vol 49, Issue 10, p2341
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0374-5