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- Title
The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes.
- Authors
Kretowski, A; Hokanson, J E; McFann, K; Kinney, G L; Snell-Bergeon, J K; Maahs, D M; Wadwa, R P; Eckel, R H; Ogden, L G; Garg, S K; Li, J; Cheng, S; Erlich, H A; Rewers, M
- Abstract
Individuals with type 1 diabetes have an increased incidence of coronary artery disease (CAD) and a higher risk of cardiovascular death compared with individuals of the same age in the general population. While chronic hyperglycaemia and insulin resistance partially explain excess CAD, little is known about the potential genetic determinants of accelerated coronary atherosclerosis in type 1 diabetes. The aim of the present study was to evaluate the association of apolipoprotein A-IV (APOA4) polymorphisms with coronary artery calcification (CAC) progression, a marker of subclinical atherosclerosis.
- Publication
Diabetologia, 2006, Vol 49, Issue 8, p1946
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0317-1