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- Title
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
- Authors
Hermann, R; Lipponen, K; Kiviniemi, M; Kakko, T; Veijola, R; Simell, O; Knip, M; Ilonen, J
- Abstract
We analysed the contribution of the lymphoid protein tyrosine phosphatase (LYP) Arg620Trp variant (which corresponds to the PTPN22 C1858T polymorphism) to the emergence of beta-cell-specific humoral autoimmunity and progression to type 1 diabetes in man. We also explored the heterogeneity in the disease-predisposing effect of this polymorphism in relation to known disease loci, sex and age at disease onset.
- Publication
Diabetologia, 2006, Vol 49, Issue 6, p1198
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0225-4