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Title
Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.
Authors
Lin, J; Bierhaus, A; Bugert, P; Dietrich, N; Feng, Y; Vom Hagen, F; Nawroth, P; Brownlee, M; Hammes, H-P
Abstract
Hyperglycaemia-induced mitochondrial overproduction of reactive oxygen species (ROS) is central to the pathogenesis of endothelial damage in diabetes. R-(+)-alpha-lipoic acid has advantages over classic antioxidants, as it distributes to the mitochondria, is regenerated by glycolytic flux, and has a low redox potential.