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Title
High glucose alters the expression of genes involved in proliferation and cell-fate specification of embryonic neural stem cells.
Authors
Fu, J; Tay, S S W; Ling, E A; Dheen, S T
Abstract
Maternal diabetes induces neural tube defects during embryogenesis. Since the neural tube is derived from neural stem cells (NSCs), it is hypothesised that in diabetic pregnancy neural tube defects result from altered expression of developmental control genes, leading to abnormal proliferation and cell-fate choice of NSCs.