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- Title
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review.
- Authors
Natali, A; Ferrannini, E
- Abstract
Insulin resistance, which manifests itself as endogenous glucose overproduction and reduced insulin-mediated glucose uptake, is a core defect in type 2 diabetes. Metformin and the peroxisome proliferator-activated receptor-gamma agonists, the thiazolidinediones (TZDs), both lower glucose, although their mechanism of action is still subject to debate. This review analyses the evidence relevant to these mechanisms in vivo.
- Publication
Diabetologia, 2006, Vol 49, Issue 3, p434
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-006-0141-7