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- Title
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.
- Authors
Riggs, A C; Bernal-Mizrachi, E; Ohsugi, M; Wasson, J; Fatrai, S; Welling, C; Murray, J; Schmidt, R E; Herrera, P L; Permutt, M A
- Abstract
Wolfram syndrome is an autosomal recessive disorder characterised by childhood diabetes mellitus, optic atrophy and severe neurodegeneration, resulting in premature death. The aim of this study was to investigate the mechanisms responsible for the phenotype of carbohydrate intolerance and loss of pancreatic beta cells in this disorder.
- Publication
Diabetologia, 2005, Vol 48, Issue 11, p2313
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-005-1947-4