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- Title
Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes.
- Authors
Meier, J J; Gallwitz, B; Askenas, M; Vollmer, K; Deacon, C F; Holst, J J; Schmidt, W E; Nauck, M A
- Abstract
The insulinotropic effect of gastric inhibitory polypeptide (GIP) is reduced in patients with type 2 diabetes and around 50% of their first-degree relatives under hyperglycaemic conditions. It is unknown whether this is a result of a specific defect in GIP action or of a general reduction in beta cell function. Moreover, impaired secretion of glucagon-like peptide 1 (GLP-1) has been described in patients with type 2 diabetes. Therefore, we studied the insulinotropic effect of GIP in women with previous gestational diabetes (pGDM) under euglycaemic fasting conditions and during a hyperglycaemic clamp experiment. The secretion of GIP and GLP-1 was assessed following oral glucose ingestion.
- Publication
Diabetologia, 2005, Vol 48, Issue 9, p1872
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-005-1863-7