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- Title
Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes.
- Authors
Katakami, N; Yamasaki, Y; Hayaishi-Okano, R; Ohtoshi, K; Kaneto, H; Matsuhisa, M; Kosugi, K; Hori, M
- Abstract
Metformin is a well-known oral hypoglycaemic agent and has been commonly used, in combination with sulphonylurea, to treat type 2 diabetes. However, the advantageous effect of metformin plus sulphonylurea on diabetic macroangiopathy has yet to be clarified. To evaluate whether sulphonylurea or sulphonylurea plus metformin prevent diabetic macroangiopathy, we examined the progression of carotid artery intima-media thickness (IMT) as a surrogate end point.
- Publication
Diabetologia, 2004, Vol 47, Issue 11, p1906
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-004-1547-8