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- Title
Effects of insulin-sensitising agents in mice with hepatic insulin resistance.
- Authors
Cohen, S E; Tseng, Y-H; Michael, M D; Kahn, C R
- Abstract
The metabolic abnormalities of insulin resistance are ameliorated by insulin sensitisers via different mechanisms. Metformin decreases hepatic glucose output, whereas rosiglitazone (RSG) is an agonist for peroxisome proliferator activated receptor (PPAR)gamma, highly expressed in fat. To gain insight into the mechanisms of action of these drugs, we compared their actions in two models of insulin resistance: the obese, hyperglycaemic ob/ob mouse and the liver specific insulin receptor knockout (LIRKO) mouse.
- Publication
Diabetologia, 2004, Vol 47, Issue 3, p407
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-003-1320-4