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- Title
Intrauterine programming of fetal islet gene expression in rats--effects of maternal protein restriction during gestation revealed by proteome analysis.
- Authors
Sparre, T; Reusens, B; Cherif, H; Larsen, M R; Roepstorff, P; Fey, S J; Mose Larsen, P; Remacle, C; Nerup, J
- Abstract
Fetal undernutrition can result in intrauterine growth restriction and increased incidence of Type 2 diabetes mellitus. Intrauterine malnutrition in form of an isocaloric low-protein diet given to female rats throughout gestation decreases islet-cell proliferation, islet size and pancreatic insulin content, while increasing the apoptotic rate and sensitivity to nitrogen oxide and interleukin-1beta. Hence, the influence of a low-protein diet on the development of beta-cells and islets could also be of interest for the pathogenesis of Type 1 and Type 2 diabetes mellitus. We hypothesise that the effects of a low-protein diet in utero are caused by intrauterine programming of beta-cell gene expression.
- Publication
Diabetologia, 2003, Vol 46, Issue 11, p1497
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-003-1208-3