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- Title
Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment.
- Authors
Etoh, T; Inoguchi, T; Kakimoto, M; Sonoda, N; Kobayashi, K; Kuroda, J; Sumimoto, H; Nawata, H
- Abstract
An increased production of reactive oxygen species (ROS) could contribute to the development of diabetic nephropathy. NAD(P)H oxidase might be an important source of ROS production in kidney as reported in blood vessels. In this study, we show the increased expression of essential subunits of NAD(P)H oxidase, NOX4 and p22phox, in the kidney of diabetic rats.
- Publication
Diabetologia, 2003, Vol 46, Issue 10, p1428
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-003-1205-6