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- Title
Rosiglitazone and pulmonary oedema: an acute dose-dependent effect on human endothelial cell permeability.
- Authors
Idris, I; Gray, S; Donnelly, R
- Abstract
Peripheral and pulmonary oedema has emerged as the most common drug-related side effect of rosiglitazone in clinical practice, but the underlying mechanisms are not clear. Fluid retention and changes in vascular tone could contribute to oedema formation, but the interpretation of clinical and in vivo studies is particularly difficult and the direct effects of thiazolidinediones on endothelial barrier function have not been previously reported.
- Publication
Diabetologia, 2003, Vol 46, Issue 2, p288
- ISSN
0012-186X
- Publication type
Journal Article
- DOI
10.1007/s00125-002-1008-1